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11Role of PGC-1alpha in exercise training- and resveratrol-induced prevention of age-associated inflammation.
Olesen J; Ringholm S; Nielsen MM; Brandt CT; Pedersen JT; Halling JF; Goodyear LJ; Pilegaard H
Exp Gerontol 2013; 48(11): 1274-84
PubMed ID: 23916840

BACKGROUND/AIM: Age-related metabolic diseases are often associated with low-grade inflammation. The aim of the present study was to investigate the role of the transcriptional co-activator PGC-1alpha in the potential beneficial effects of exercise training and/or resveratrol in the prevention of age-associated low-grade inflammation. To address this, a long-term voluntary exercise training and resveratrol supplementation study was conducted. EXPERIMENTAL SETUP: Three month old whole body PGC-1alpha KO and WT mice were randomly assigned to four groups: untrained chow-fed, untrained chow-fed supplemented with resveratrol, chow-fed voluntarily exercise trained and chow-fed supplemented with resveratrol and voluntarily exercise trained. The intervention lasted 12 months and three month old untrained chow-fed mice served as young controls. RESULTS: Voluntary exercise training prevented an age-associated increase (p<0.05) in systemic IL-6 and adiposity in WT mice. PGC-1alpha expression was required for a training-induced prevention of an age-associated increase (p<0.05) in skeletal muscle TNFalpha protein. Independently of PGC-1alpha, both exercise training and resveratrol prevented an age-associated increase (p<0.05) in skeletal muscle protein carbonylation. CONCLUSION: The present findings highlight that exercise training is a more effective intervention than resveratrol supplementation in reducing age-associated inflammation and that PGC-1alpha in part is required for the exercise training-induced anti-inflammatory effects. (c) 2013. Olesen, Jesper

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