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Centre of Inflammation and Metabolism (CIM)


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87Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest.
Kiilerich K; Ringholm S; Bienso RS; Fisher JP; Iversen N; van Hall G; Wojtaszewski JF; Saltin B; Lundby C; Calbet JA; Pilegaard H
J Appl Physiol 2011; 111(3): 751-7
PubMed ID: 21680880

To test the hypothesis that physical inactivity impairs the exercise-induced modulation of pyruvate dehydrogenase (PDH), six healthy normally physically active male subjects completed 7 days of bed rest. Before and immediately after the bed rest, the subjects completed an oral glucose tolerance test (OGTT) and a one-legged knee extensor exercise bout [45 min at 60% maximal load (W(max))] with muscle biopsies obtained from vastus lateralis before, immediately after exercise, and at 3 h of recovery. Blood samples were taken from the femoral vein and artery before and after 40 min of exercise. Glucose intake elicited a larger (P

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