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139Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans.
Berg RM; Taudorf S; Bailey DM; Lundby C; Larsen FS; Pedersen BK; Moller K
Crit Care 2010; 14(1): R16
PubMed ID: 20149231

ABSTRACT: INTRODUCTION: Alterations in circulating large neutral amino acids (LNAA), leading to a decrease in the plasma ratio between branched-chain and aromatic amino acids (BCAA/AAA ratio) may be involved in sepsis-associated encephalopathy. We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation. METHODS: The BCAA/AAA ratio, the cerebral delivery and net exchange of LNAA and ammonia were measured before and one hour after a four-hour intravenous infusion of Escherichia coli lipopolysaccharide (LPS) in twelve healthy young men. RESULTS: LPS induced systemic inflammation, reduced the BCAA/AAA ratio, increased the cerebral delivery and unidirectional influx of phenylalanine, and abolished the net cerebral influx of the BCAAs leucine and isoleucine. Furthermore, a net cerebral efflux of glutamine, which was independent of the cerebral net exchange of ammonia, was present after LPS infusion. CONCLUSIONS: Systemic inflammation may affect brain function by reducing the BCAA/AAA ratio, thereby changing the cerebral net exchange of LNAAs. ENG JOURNAL ARTICLE 20100211

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