Tuesday, September 16, 2014 Print page
 
Centre of Inflammation and Metabolism (CIM)
 

The Centre of Inflammation and Metabolism

On this website you will find information about people, research projects, publications, meetings at CIM.

In Denmark, physical inactivity is considered the number two actual cause of death. Physically inactive people have a life span which is 5 years shorter than physically active. Type 2 diabetes, cardiovascular diseases, colon cancer, breast cancer, dementia and depression constitute a cluster of diseases, which defines 'a diseasome of physical inactivity'. The finding that muscles produce and release myokines provides a conceptual basis to understand the mechanisms whereby exercise offers protection against diseases with very different phenotypical presentation. According to our theory, skeletal muscle is an endocrine organ that releases myokines, which work in a hormone-like fashion, exerting specific endocrine effects on visceral fat, brain, liver and other organs. Other myokines work locally within the muscle via paracrine mechanisms, exerting their effects on signalling pathways involved in e.g. fat oxidation.

We apply a unique research concept, in which we initially perform in-depth mechanistic studies in Homo sapiens and continue by backing these up with further studies in animal models and human primary cell cultures to unravel the molecular mechanisms whereby muscle communicates to other organs. The regulatory pathways and biological roles of most of the recently identified potential myokine candidates are totally unknown. Using sophisticated screening approaches in vitro and in vivo, we aim to uncover novel myokines that specifically target ectopic fat mass. This multi-disciplinary and unconventional strategy may be classified as “from man to molecule”.

CIM is located at Rigshospitalet and cooperates closely with the University of Copenhagen and the University of Southern Denmark.

CIM is supported by

The Danish National Research Foundation

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© 2014 Centre of Inflammation and Metabolism
www.inflammation-metabolism.dk