Sunday, April 20, 2014 Print page
Centre of Inflammation and Metabolism (CIM)

The Centre of Inflammation and Metabolism

On this website you will find information about people, research projects, publications, meetings at CIM.

In Denmark, physical inactivity is considered the number two actual cause of death. Physically inactive people have a life span which is 5 years shorter than physically active. Type 2 diabetes, cardiovascular diseases, colon cancer, breast cancer, dementia and depression constitute a cluster of diseases, which defines 'a diseasome of physical inactivity'. The finding that muscles produce and release myokines provides a conceptual basis to understand the mechanisms whereby exercise offers protection against diseases with very different phenotypical presentation. According to our theory, skeletal muscle is an endocrine organ that releases myokines, which work in a hormone-like fashion, exerting specific endocrine effects on visceral fat, brain, liver and other organs. Other myokines work locally within the muscle via paracrine mechanisms, exerting their effects on signalling pathways involved in e.g. fat oxidation.

We apply a unique research concept, in which we initially perform in-depth mechanistic studies in Homo sapiens and continue by backing these up with further studies in animal models and human primary cell cultures to unravel the molecular mechanisms whereby muscle communicates to other organs. The regulatory pathways and biological roles of most of the recently identified potential myokine candidates are totally unknown. Using sophisticated screening approaches in vitro and in vivo, we aim to uncover novel myokines that specifically target ectopic fat mass. This multi-disciplinary and unconventional strategy may be classified as “from man to molecule”.

CIM is located at Rigshospitalet and cooperates closely with the University of Copenhagen and the University of Southern Denmark.

CIM is supported by

The Danish National Research Foundation



New/updated publications on this website

Regulation of PDH in human arm and leg muscles at rest and during intense exercise.

PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle.

Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle.

Altered free radical metabolism in acute mountain sickness: implications for dynamic cerebral autoregulation and blood-brain barrier function.

Acute myocardial infarction and syncope in an 18-year-old athlete with an abnormal origin of the left coronary artery: a case report.

Circulating levels of vasoactive peptides in patients with acute bacterial meningitis.

Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness.

Change in Hemoglobin Levels due to Anesthesia in Mice: An Important Confounder in Studies on Hematopoietic Drugs.

In Vivo Imaging of Far-red Fluorescent Proteins after DNA Electrotransfer to Muscle Tissue.

Utility of lead aVR for identifying the culprit lesion in acute myocardial infarction.

Apolipoprotein M predicts pre-beta-HDL formation: studies in type 2 diabetic and nondiabetic subjects.

Stable isotope labeling by amino acids in cell culture (SILAC) and quantitative comparison of the membrane proteomes of self-renewing and differentiating human embryonic stem cells.

Cerebral blood flow and oxygen metabolism measured with the Kety-Schmidt method using nitrous oxide.

Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality.

Single nucleotide polymorphisms in inflammatory genes and the risk of early onset of lone atrial fibrillation.

Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat.

Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle.

Endurance exercise induces mRNA expression of oxidative enzymes in human skeletal muscle late in recovery.

Contraction-induced changes in skeletal muscle Na(+), K(+) pump mRNA expression - importance of exercise intensity and Ca(2+)-mediated signalling.

Effects of erythropoietin administration on cerebral metabolism and exercise capacity in men.

Click here to see all publications



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